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Record 1
from database: MEDLINE
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- Title
- Inhibition of cell growth in culture
by quinones.
- Author
- Kamei H; Koide T; Kojima T; Hashimoto
Y; Hasegawa M
- Address
- Department of Surgery, Aichi-Gakuin
University Hospital, Japan. kamei@dpc.aichi-gakuin.ac.jp
- Source
- Cancer Biother Radiopharm, 1998 Jun,
13:3, 185-8
- Abstract
- Quinones were studied for their growth
inhibitory effect on cultured malignant
cells. HCT-15 cells derived from human
colon carcinoma were used for these
experiments. Quinones used were arbutin
in the benzoquinone group, juglone and
lawsone in the naphthaquinone group,
alizarin, emodin,
1,8-dihydroxyanthraquinone, and
anthraquinone in the anthraquinone
group, and xanthone. Cultured cells were
incubated with various concentrations of
the quinones for four days in a 5% CO2
incubator, after which cell numbers were
counted and significance of differences
was analyzed by Student's t test.
Anthraquinones and naphthaquinones used
in these experiments were more effective
than the monocyclic quinone. The 50%
suppression dose was less than 12.5
micrograms/ml for them. The number of OH
groups seemed to play an important role
in the degree of the cell growth
inhibition: anthraquinones with 2 or 3
OH groups were more effective than those
with no OH group like,
9,10-dioxoanthracene and xanthone. In
fact, anthraquinones with no OH group
and xanthone were not significantly
effective. Flow cytometric histograms
revealed a specific pattern; that is,
lawsone and juglone in the
naphthaquinone group and alizarin and
1,8-dihydroxy-anthraquinone in the
anthraquinone group blocked mainly the S
phase, and emodin in the anthraquinone
group blocked the G1 to S phase of the
cell cycle.
- Language of Publication
- English
- Unique Identifier
- 20308900
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- MeSH Heading (Major)
- Antineoplastic Agents|*TO; Cell
Division|*DE; Quinones|*TO
- MeSH Heading
- Anthraquinones|TO; Arbutin|TO; Colonic
Neoplasms; Human; Naphthoquinones|TO;
Support, Non-U.S. Gov't; Tumor Cells,
Cultured; Xanthenes|TO
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1084-9785
- Country of Publication
- UNITED STATES
Record 2
from database: MEDLINE
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- Title
- Anti-implantation activity of 2
derivatives of o-hydroxy naphthaquinones
in rats.
- Author
- Dhar SK; Mattu S
- Address
- Pharmacology Division, Regional
Research Laboratory, Jammu Tawi, India.
- Source
- Chung Kuo Yao Li Hsueh Pao, 1995 Sep,
16:5, 471-2
- Abstract
- AIM: To search for female
contraceptive agents. METHODS:
2-Hydroxy-3-methyl-1, 4-naphthoquinone
monosemicarbazone (HMNQS) and
2-hydroxy-1, 4-naphthoquinone
monothiosemicarbazone (HNQTS) were
screened for anti-implantation activity
in rats. RESULTS: Both compounds showed
a dose-dependent activity, and HNQTS was
more potent. An 100% anti-implantation
activity was observed with HNQTS 150 mg
kg-1 ig. Its LD50 was found to be > 2
g kg-1 ig in mice. CONCLUSION: HNQTS was
more potent than HMNQS for
anti-implantation activity in rats.
- Language of Publication
- English
- Unique Identifier
- 96287051
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- MeSH Heading (Major)
- Contraceptives, Postcoital,
Synthetic|*PD/TO; Naphthoquinones|*PD/TO;
Ovum Implantation|*DE
- MeSH Heading
- Animal; Female; Male; Mice; Organ
Weight|DE; Rats; Uterus|AH
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0253-9756
- Country of Publication
- CHINA
Record 3
from database: MEDLINE
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- Title
- Anti-tumor promoting effects of
naphthoquinone derivatives on short term
Epstein-Barr early antigen activation
assay and in mouse skin carcinogenesis.
- Author
- Kapadia GJ; Balasubramanian V; Tokuda
H; Konoshima T; Takasaki M; Koyama J;
Tagahaya K; Nishino H
- Address
- Department of Pharmaceutical Sciences,
College of Pharmacy and Pharmaceutical
Sciences, Howard University, Washington,
D.C. 20059, USA.
- Source
- Cancer Lett, 1997 Feb, 113:1-2, 47-53
- Abstract
- In continuation of our studies of
natural and synthetic products as cancer
chemopreventive agents, we have examined
a number of naphthoquinone derivatives
including monomeric, dimeric and
tetrameric naphthaquinones occurring in
the Diospyros and other selected plant
genera. Several synthetic
naphthoquinones were also evaluated.
Initially these compounds were tested
for in vitro anti-tumor promoting effect
on Epstein-Barr virus early antigen
activation produced by the tumor
promoter
12-O-tetradecanoylphorbol-13-acetate (TPA)
and thereafter in in vivo on two-stage
mouse skin carcinogenesis. Our studies
show some of these compounds have potent
anti-tumor promoting activity.
- Language of Publication
- English
- Unique Identifier
- 97218139
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- MeSH Heading (Major)
- Antigens, Viral|DE/*ME;
Naphthoquinones|*PD; Papilloma|CI/*PC;
Skin Neoplasms|CI/*PC
- MeSH Heading
- Animal; Carcinogens; Cells, Cultured;
Female; Mice; Mice, Inbred ICR; Support,
Non-U.S. Gov't; Support, U.S. Gov't,
Non-P.H.S.; Tetradecanoylphorbol Acetate
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0304-3835
- Country of Publication
- IRELAND
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