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Lapacho (Pau D'Arco, Taheebo, Ipe Roxo)

Source

Check out the Witch Doctors article.

Tabebuia impetiginosa (a.k.a T. avellanedae) is tree species in the family Bignoniaceae (catalpa family) native to rainforests throughout Central and South America. Mainly exported from Argentina, Paraguay, and Brazil, its common names include lapacho, pau d'arco, taheebo, and ipe roxo.

Popular reports indicate that the bark of this tree and of several other related members of Tabebuia and Tecoma curialis are used in Central and South American folk medicine to make a tea that is used to treat a wide range of maladies, from arthritis to ulcers to diabetes to cancer. As a result, many herb companies and health food stores in the U.S. are vigorously promoting lapacho teas as a virtual cure-all.


Pharmacology of ß-Lapachone and Lapachol

[image of beta-lapachone and lapachol
molecules]
Beta-lapachone, a quinone, is derived from lapachol (a naphthoquinone) which can be isolated from the lapacho tree (Tabebuia avellanedae), a member of the catalpa family (Bignoniaceae). Like camptothecin and topotecan, ß-lapachone inhibits DNA topoisomerase I. Researchers have found that this compound has promising anticancer and antiviral properties.

 

Topoisomerase inhibitors, including beta-lapachone, seem to be effective against several types of cancer, including lung, breast, colon and prostate cancers and malignant melanoma. The use of beta-lapachone in humans has been limited due to its toxicity. However, 3-allyl-beta-lapachone (a close chemical relative) has been found to have lower toxicity in cell culture tests, and therefore may prove to be more useful than beta-lapachone.

[Karl Note:  While there may be some toxicity to individual components of the taheebo bark, none have been claimed for the whole bark in a concentrated extract form.  The whole bark apparently contains components which neutralize any others that might be toxic by themselves.]

 

Beta-lapachone works by disrupting DNA replication. Topoisomerase I is an enzyme that unwinds the DNA that makes up the chromosomes. The chromosomes must be unwound in order for the cell to use the genetic information to synthesize proteins; beta-lapachone keeps the chromosomes wound tight, and so the cell can't make proteins. As a result, the cell stops growing. Because cancer cells grow and reproduce at a much faster rate than normal cells, they are more vulnerable to topoisomerase inhibition than are normal cells. Beta-lapachone also interferes with the replication of HIV-1, a virus that causes AIDS, thereby slowing the advancement of the disease.

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