Life Glow Plus contains 250 mcg of selenium and Super Life Glow contains a similar amount.
Here is a scientific comment on this substance:
Can selenium prevent cancer? Epidemiological study expanded to investigate selenium's impact on multiple cancers
Although changing lifestyle habits to reduce cancer risk may present tough personal challenges, environmental risk factors are often less obvious and harder to change. To draw conclusions about the causes of disease and formulate prevention strategies, epidemiologists study whole populations and devote years of research to meticulous data collection.
Since 1981, the Arizona Cancer Center's Epidemiology Director Larry C.
Clark, Ph.D., has been studying East coast residents who are at high risk for skin cancer.
Spanning more than a decade, the Nutritional Prevention of Cancer Project has recruited
1,700 healthy people from South Carolina, North Carolina, Georgia, Florida, and
Connecticut to test the effectiveness of selenium as a skin cancer preventive agent.
Dr. Clark and his collaborators from Cornell University, Professor of Nutrition Gerald
Combs Jr., Ph.D., and Professor of Statistics Bruce Turnbull, Ph.D., chose this population
for their study because of their skin cancer risk and because they live in an area with
little dietary selenium.
Most Americans get their daily doses of selenium from the food they eat. Selenium in the
soil is absorbed by plants and, subsequently, by the people and animals who eat them. In
the United States, selenium intake is highly variable, ranging from 60 to more than 200
micrograms per day, with an average of about 125 micrograms. Americans on the Eastern
Coastal Plain and in the Pacific Northwest have the lowest selenium intake-60 to 90
micrograms per day.
"This project has the opportunity to determine whether dietary selenium
supplementation can prevent cancer. Because the majority of the U.S. population lives in
relatively low selenium areas, the public health implications of this project's results
may prove to be significant," says Dr. Clark.
Scientists theorize that selenium may prevent cancer by reducing the impact of primary
cancer-causing agents which damage DNA by oxidant attack. How well selenium can reduce
cancer risk may depend on a person's antioxidant intake. Antioxidants, such as vitamin C,
vitamin E, carotenoids, and selenium, may protect against oxidant damage by neutralizing
agents that can harm DNA.
With additional funding from the National Cancer Institute (NCI) the selenium research has
expanded from its initial skin cancer focus to include mortality, incidence of all cancer
types, and cancer screening. In 1993, Dr. Clark's team received a $6.1 million five-year
grant for the "Nutritional Prevention of Cancer" and a $1.5 million three-year
grant for "PSA as an Intermediate Marker for Prostate Cancer".
Their goal is to determine if selenium supplementation reduces mortality from all causes
of death-particularly melanoma, lung, prostate, and colorectal cancers. Dr. Clark's team
also is looking at selenium in relation to precancerous conditions, especially colon
polyps. In 1991, Dr. Clark and former UA gastroenterologist Lee J. Hixson, M.D., released
the findings from a pilot study which found that patients at the Tucson Veterans Affairs
Medical Center who ranked below the mean in blood selenium concentration had a much higher
prevalence of colon polyps. After these initial findings, they began screening patients
from the selenium skin cancer study for colorectal cancer to see if the colon polyp
results could be replicated in a larger population of healthy people with no
gastrointestinal complaints.
Under the new grants, the screening component calls for continuation of the colon cancer
screening and initiation of prostate specific antigen (PSA) screening. In addition to
determining PSA levels in blood samples from study participants, the PSA arm of the
research also will analyze frozen blood samples which have been gathered over the past 11
years. Bruce Dalkin, M.D., assistant professor of surgery/urology, is collaborating on the
PSA research.
Overall, the expanded selenium project is unique because the original participants were a
defined population recruited for skin cancer-not prostate or colon cancer, says Dr. Clark.
Now they are being followed for many years to see if they develop any type of cancer.
Of the 1,700 people recruited for the study, only nine have been lost to follow up, Dr.
Clark adds. He attributes this outstanding rate of participant loyalty to the fact that
they are being followed by their community dermatologists.
"This trial has made remarkable progress since the first patients were randomized in
1983. It stands out among current ongoing chemoprevention trials both because of its
length of follow up and the broad array of important endpoints which are being analyzed
for benefits from selenium supplementation," Dr. Clark adds. "The trial has
documented the safety of long-term supplementation with nutritional doses of selenium.
"Although these trends are exceedingly favorable, definitive results are necessary in
order to assure the safety and effectiveness of an intervention which may eventually be
used by millions of essentially healthy individuals."
To date, more than 10,000 person years of data have been collected. Dr. Clark's database
now catalogs more than 18,000 patient visits; 41,000 surgeries and liquid nitrogen
treatments for skin cancers; 13,000 plasma selenium analyses; 12,000 blood samples; 800
food frequency questionnaires; and 9,500 miscellaneous illnesses reported by patients.
From 1983 to the present, the Nutritional Prevention of Cancer has expanded with funding
from the American Institute for Cancer Research, the American Cancer Society, and the NCI.
The project has more than 50 collaborators, including dermatologists, urologists,
gastroenterologist, ophthalmologists, biostatistians, and epidemiologists. Collaborating
institutions include Medical College of Georgia, Cornell University, University of Miami,
and University of Connecticut.
"The results from the initial 10 years of the project will be published next and may
provide unique information since this is the only large, long-term cancer prevention trial
in the world using selenium supplementation," Dr. Clark adds.
This article was originally published in 1993-94 Report of the Arizona Cancer Center. News
media may quote this article, but we request that credit be given. For a copy of this
document or other Cancer Center publications, see instructions under
"Publications" heading. Correspondence regarding editorial content or
circulation should be addressed to the Editor, Arizona Cancer Center, Tucson, AZ 85724;
phone 520-626-2277 or E-mail to ppowers@azcc.arizona.edu. Copyright 1994 ABOR. All rights
reserved.
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