Golden Seal
Contained in Super Life Glow
HealthGate Document
Record 1 from database: MEDLINE
- Title
- Evaluation of traditional plant treatments for diabetes: studies in streptozotocin
diabetic mice.
- Author
- Swanston-Flatt SK; Day C; Bailey CJ; Flatt PR
- Address
- Department of Biological and Biomedical Sciences, University of Ulster, Coleraine, U.K.
- Source
- Acta Diabetol Lat, 1989 Jan-Mar, 26:1, 51-5
- Abstract
- Seven plants and a herbal mixture used for traditional treatment of diabetes were
studied in streptozotocin diabetic mice. The treatments were supplied as 6.25% by weight
of the diet for 9 days. Consumption of diets containing bearberry (Arctostaphylos
uva-ursi), golden seal (Hydrastis canadensis), mistletoe (Viscum album) and tarragon
(Artemisia dracunculus) significantly reduced the hyperphagia and polydipsia associated
with streptozotocin diabetes, but bayberry (Cinnamomum tamala), meadowsweet (Filipendula
ulmaria), senna (Cassia occidentalis) and the herbal mixture did not alter these
parameters. Bearberry, mistletoe and tarragon retarded the body weight loss but none of
the eight treatments significantly altered plasma glucose or insulin concentrations. These
studies suggest that bearberry, golden seal, mistletoe and tarragon may counter some of
the symptoms of streptozotocin diabetes without, however, affecting glycemic control.
- Language of Publication
- English
- Unique Identifier
- 89319498
- MeSH Heading (Major)
- Diabetes Mellitus, Experimental|*TH; Medicine, Traditional|*; Plants, Medicinal|*
- MeSH Heading
- Animal; Body Weight; Comparative Study; Energy Intake; Herbs; Male; Mice; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-5563
- Country of Publication
- ITALY
Record 2 from database: MEDLINE
- Title
- Adulterants causing false negatives in illicit drug testing.
- Author
- Mikkelsen SL; Ash KO
- Address
- Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132.
- Source
- Clin Chem, 1988 Nov, 34:11, 2333-6
- Abstract
- Illicit-drug users may attempt to falsify results by in vitro adulteration of specimens.
We investigated eight additives (NaCl, Visine, handsoap, Drano, bleach, vinegar,
golden-seal tea, and lemon juice) claimed by drug users to invalidate enzyme immunoassay
(EIA) drug assays. We also analyzed adulterated urine specimens to determine if they could
be identified, adding adulterants at several concentrations to 222 EIA-positive specimens
confirmed by gas chromatography and mass spectrometry (GC/MS) to contain illicit drugs. To
identify adulterated urines, we monitored pH, relative density, and urine color and
turbidity at adulterant concentrations that falsified EIA results. Specimens contaminated
with NaCl had relative densities greater than 1.035. Liquid Drano, bleach, and vinegar
shifted urine pH outside the physiological range. Golden-seal tea caused a dark
appearance, and specimens containing liquid soap were unusually cloudy. Lemon juice had no
effect on the assays. Visine was the only adulterant not detected. The adulterants
interfered somewhat differently with each of the drug assays. EIA assays for illicit drugs
can be invalidated by specimen adulteration producing false-negative results. Therefore,
if urine drug testing is to be conducted, pH, relative density, and appearance should be
assessed and suspect specimens should be rejected. Not all adulterants can be detected, so
observed collection is strongly recommended.
- Language of Publication
- English
- Unique Identifier
- 89029118
- MeSH Heading (Major)
- Detergents|*; Street Drugs|*UR; Surface-Active Agents|*
- MeSH Heading
- Acetic Acids; Amphetamines|UR; Barbiturates|UR; Benzodiazepines|UR; Cannabinoids|UR;
Cocaine|UR; False Negative Reactions; Human; Hydrogen-Ion Concentration; Imidazoles;
Immunoenzyme Techniques; Mass Fragmentography; Narcotics|UR; Sodium Chloride; Tea
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0009-9147
- Country of Publication
- UNITED STATES
- CAS Registry/EC Number
- 0 (Amphetamines); 0 (Benzodiazepines); 0 (Cannabinoids); 0 (Detergents); 0 (Imidazoles);
0 (Narcotics); 0 (Street Drugs); 0 (Surface-Active Agents); 50-36-2 (Cocaine); 64-19-7
(Acetic Acid); 7647-14-5 (Sodium Chloride); 84-22-0 (tetrahydrozoline)
Record 3 from database: MEDLINE
- Title
- CEDIA for screening drugs of abuse in urine and the effect of adulterants.
- Author
- Wu AH; Forte E; Casella G; Sun K; Hemphill G; Foery R; Schanzenbach H
- Address
- Toxicology Laboratory, Hartford Hospital, CT, USA.
- Source
- J Forensic Sci, 1995 Jul, 40:4, 614-8
- Abstract
- The performance of the Microgenics CEDIA DAU assays for screening amphetamines,
barbiturates, benzodiazepines, cocaine, opiates, phencylidine (PCP), and
tetrahydrocannabinol (THC) was evaluated on the Boehringer Mannheim/Hitachi 717 in urine.
Limits of detection ranged from 0.6 ng/mL for PCP, to 34.1 ng/mL for benzodiazepines. The
average within run and total precision for these assays ranged from 1.3 to 7.3% for
controls at cutoff concentrations, and control values at -25% and +25% of cutoffs. The
rate separations by CEDIA between the negative and cutoff calibrators for all drugs were
greater than corresponding EMIT II (Syva Co.) assays. The relative sensitivity and
specificity of CEDIA as compared to EMIT II were 95.6 and 98.8%, respectively, on 13,535
urine samples. All positive samples, and those samples producing discordant results
between the assays were confirmed by quantitative gas chromatography/mass spectrometry
(GC/MS). Using SAMHSA cutoff limits (and including barbiturates and benzodiazepines at 300
ng/mL), the relative sensitivity and specificity of CEDIA vs. EMIT II were 96.7 and 98.8%,
respectively. The overall sensitivity of CEDIA vs. GC/MS was 98.9% with 179 false
positives, as compared to 96.2% with 189 false positives for EMIT II vs. GC/MS. The effect
of adulterants added to urine to potentially invalidate screening results was also tested.
CEDIA produced strong interferences for most drug assays in the presence of
glutaraldehyde, detergent, and high concentrations of bleach and Drano. Minimal or
selective interferences were seen with golden seal tea lemon juice, Visine, and low
concentrations of bleach and Drano. Essentially no interference was observed with
bicarbonate, sodium chloride, and vinegar.
- Language of Publication
- English
- Unique Identifier
- 96078554
- MeSH Heading (Major)
- Immunoenzyme Techniques|*; Substance-Related Disorders|*UR
- MeSH Heading
- Comparative Study; Human; Mass Fragmentography; Reproducibility of Results; Sensitivity
and Specificity; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-1198
- Country of Publication
- UNITED STATES
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