The Mechanics of HOW Chelation Works
How about YOUR question here?
Read below or choose another question.
My opinion, and that of others, is that
chelation therapy offers the brightest promise of health help on the medical
horizon today!
Probably the foremost authority and expert on
chelation therapy today is Dr. Elmer Cranton, author of Bypassing Bypass, and
other Books. He says:
Free Radical Causes of Degenerative
Disease
The field of free radical biochemistry is as
revolutionary and profound in its implications for medicine as the germ theory
was for the science of microbiology. It has created a new paradigm for viewing
the disease process. Emerging knowledge in this field gives us a compelling
scientific rationale for treatment and prevention of major causes of long-term
disability and death with EDTA chelation therapy.(98-107) (source)
It is increasingly being accepted that free
radicals are the SOLE cause of heart disease and cancer. These two diseases are
responsible for over 70% of all death in Western Society. Most doctors do
not yet acknowledge this truth.
There is no direct equivalent between
intravenous chelation and oral chelation. I consider Dr. Cranton the
foremost expert on intravenous chelation therapy. Yet he claims that oral
chelation is quackery! I disagree with him. So, I mostly quote his
explanations of IV chelation, and try to compare it with oral chelation --
here.
You can get an approximate relationship between the
two.
First let's look at the word "chelate."
The word means to "bind" or to "grab." Chelation is the
process of some substance (such as EDTA, Cysteine or N Acetyl Cysteine) grabbing
a heavy metal.
Metals are grabbed in a sequential sequence, per Dr.
Cranton:
The affinity of EDTA to bind various metals
at physiologic pH, in order of decreasing stability, is listed below. In the
presence of a more tightly bound metal, EDTA releases metals lower in the
series and binds to the metal for which it has a greater affinity.(273)
Calcium is near the bottom of the list.
Chromium 2+
Iron 3+
Mercury
2+
Copper 2+
Lead 2+
Zinc 2+
Cadmium 2+
Cobalt
2+
Aluminum 3+
Iron 2+
Manganese 2+
Calcium
2+
Magnesium 2+
(source)
Thus the chelating substance start off bound to calcium, so
it cannot pick up any new calcium. This, incidentally, is
the proving evidence that chelation does NOT remove
calcium blockage from the arteries -- as many IV
chelation doctors still claim!.
But it is the nature of a chelating substance to "let
go" of the lighter mineral in order to grab the heavier
metal, or more accurately, the metals in the sequence
shown in the above list provided by Dr. Cranton.
Thus the chelating substance starts off bound to calcium, but
it would let go of the calcium if it "bumps into" iron, or even Aluminum.
It would then let go of the aluminum if it bumps into lead. Then, bound to
lead if it bumps into iron, it would NOT let go of the lead to bind to the
iron.
When you are dealing with the artificial amino acid, EDTA,
about half of it stays in the blood stream for an hour or so -- so it is binding
to, and letting go of, heavy metals during that hour, then it is ejected from
the body through the kidneys and urine. The body
considers it a "foreign substance" from the very start
and wants to get rid of it. That is why it stays active
in the body for such a short time.
Cysteine and N Acetyl Cysteine, however, are natural amino
acids. They can stay active in the blood stream for many hours (until they
are used for chelating, used for protein structure building, or converted to
sugar). When EDTA is taken orally it works to bind to metals in the
stomach and intestine. It can also attract metals from inside the body,
through the intestinal wall, to be bound to the EDTA in
the intestine. This EDTA would remain active as long as
it is in the stomach and intestine. Since the
contents of the stomach would usually stay inside the
body for about 24 hours or so, EDTA is active longer when
taken orally than when taken intravenously.
Thus, oral chelation "works" in the body for more hours than
does IV chelation using EDTA only.
Those particles of Cysteine and NAC
that bind to metals? They would
then be considered a "foreign
particle" by the body and processed through the kidney
for elimination in the urine. The same would be
true of the small amount of EDTA that is absorbed into
the body when taken orally.
Intravenous chelation generally relies
only on the artificial Amino Acid, EDTA, and generally
about 2,000 mg of the EDTA is put into a water solution
and dripped into one of your veins over a two or three
hour period. Sometimes 3,000 mg of EDTA is used.
Generally 100% of this EDTA would be in the blood stream,
since it is put directly there.
Oral chelation depends on nutrients being useful when taken
through the mouth. Generally the "chelating substances" are EDTA, Cysteine
and N Acetyl Cysteine. Cysteine and NAC are easily absorbed through the
mouth into the body and blood stream, Since EDTA is an "artificial amino
acid" it is not readily absorbed into the body when taken through the
mouth. The Cysteine and NAC would do their chelating in the normal fashion
of any chelating substance, when taken through the mouth. Since only about
5% of EDTA taken orally gets into the blood, the 95% moves through the stomach
and intestines -- where the "chelating action" is different than when the
chelating substances is in the blood stream.
The one or two hours are called the "half life"
of the EDTA. In about 2 hours, half of the EDTA has been processed out of
the blood stream, through the kidneys, and into the bladder, in the urine,
awaiting elimination. The other half of the EDTA would be working longer,
but you can see that if half of the EDTA is "used up" every two hours, there
would be very, very little left after say 8 hours.
Now, if you just put EDTA in water, there would normally
not be any metals in the water and it might hang on to calcium or it might let
go of calcium -- depending on what WAS in the water.
But, in your body we don't want the EDTA to grab calcium,
so the calcium and EDTA are deliberately included in the same dose -- and in
most cases the EDTA will let go of the calcium it came in with, and grab
something heavier.
So you now have this interesting action --
oral EDTA is removing
metals from the food you have just eaten, but it is also removing metals from
inside the body -- attracting them from inside the body to move through the wall
of the intestine, into the feces in the intestine, to bind with the EDTA that is
still there.
The other ingredients in the formula, mostly cysteine and
NAC, bind to metals from inside the body -- and do it in the same sequential
fashion.
The only minerals that could be removed during chelation
would be those that are heavier than calcium = most of them are harmful.
Zinc is heavier, and not harmful, but my formula provides lots of zinc,
anyway.
The EDTA which is moving through the stomach? Well,
it is NOT going to be eliminated through the kidneys, but through the
feces. Thus, THIS EDTA will actually have a longer time of
effectiveness. The EDTA will remain effective in the intestine as long as
it is still in the intestine -- that would usually be about 24 hours.
During that time it is constantly grabbing metals, letting go of the lighter
ones and switching to the heavier metals.
In this sense EDTA taken orally is much more effective than
EDTA taken intravenously.
When you chelate with Cysteine, or NAC, or intravenous
EDTA, you would look in the urine to test for how much metal is being dumped
from the body. A urine test before using the chelating materials, and another
urine test (for metals) within a couple days after starting the chelating --
would tell you how much of an increase in metal there is. It would not be
unusual for the increase in metal in the urine to be as much as FIFTY
TIMES!
Now, the EDTA going through the stomach and intestine?
It is not being eliminated in the urine, but in the feces, so if you really
wanted to do the proper test you would check a "stool sample" before and after
starting the oral EDTA.
You can see, now that it is a complex question to try to
compare intravenous with oral chelation.
If a person is taking the recommended dose of Super Life
Glow, he is getting 1,800 mg of daily chelating materials, of which 500 mg is
EDTA.
If a person is taking an IV treatment, he would be getting
between 2,000 and 3,000 mg of EDTA. The EDTA would NOT be active for very
long when taken intravenously, and would be active longer when taken
orally.
There is another issue. Intravenous EDTA would be all
working within the blood stream, and generally its ONLY action would be to
remove metals.
Cystine and NAC, however, would not be active ONLY as
binding materials. These are natural amino acids and the body may well have
other uses for them besides chelating metals. It would not be very
possible to know how much Cysteine, for instance, would be used to remove metals
and how much would be used for other purposes in the body.
Is this a complex question? or not?
Finally, perhaps the best way of comparing is to simply
look at results of use, rather than the mechanics of action.
EDTA taken intravenously seems faster than oral
chelation. People will often get dramatic changes in their body after only
three or four IV treatments. These dramatic changes usually take 30 days
with oral chelation.
My personal belief on this is that if you have an urgent
need for fast action, IV chelation would be the best way to go.
But, after about 30 days, or perhaps 60, I think the daily
oral chelation would be at least as effective, and probably more effective, than
a series of 30 treatments of IV EDTA.
I have a complete analysis of one of the most recent
approaches to chelation -- using EDTA in a suppository. It would be more
effective through the mouth, since it would stay active longer, but the
suppositories are being hyped as prescription only, provided only by doctors,
and costing as much as $50 for one suppository containing 750 mg of EDTA.
Click
here for that story.
There are also many examples of different combinations of the
three different oral chelation formulas -- click
here.
One more thing.
Mercury is a common toxic metal in the body. It is
generally accepted that EDTA, taken intravenously, does NOT remove
mercury. However, Cysteine and N Acetyl Cysteine do remove
mercury. So, intravenous EDTA is not useful in removing one of the most
dangerous of all toxic metals we have in our bodies, while oral chelation does
remove mercury.
There are some interesting studies, not well known or
validated, that show that oral EDTA may, in fact remove mercury, into the
feces. This would make the oral chelation approach even more valuable than
the intravenous approach.
It is increasingly being accepted that free
radicals are the SOLE cause of heart disease and cancer. These two diseases are
responsible for over 70% of all death in Western Society. Most doctors do
not yet acknowledge this truth.
There is no direct equivalent between
intravenous chelation and oral chelation. I consider Dr. Cranton the
foremost expert on intravenous chelation therapy. Yet he claims that oral
chelation is quackery! I disagree with him. So, I mostly quote his
explanations of IV chelation, and try to compare it with oral chelation --
here.
You can get an approximate relationship between the
two.
First let's look at the word "chelate."
The word means to "bind" or to "grab." Chelation is the
process of some substance (such as EDTA, Cysteine or N Acetyl Cysteine) grabbing
a heavy metal.
Metals are grabbed in a sequential sequence, per Dr.
Cranton:
The affinity of EDTA to bind various metals
at physiologic pH, in order of decreasing stability, is listed below. In the
presence of a more tightly bound metal, EDTA releases metals lower in the
series and binds to the metal for which it has a greater affinity.(273)
Calcium is near the bottom of the list.
Chromium 2+
Iron 3+
Mercury
2+
Copper 2+
Lead 2+
Zinc 2+
Cadmium 2+
Cobalt
2+
Aluminum 3+
Iron 2+
Manganese 2+
Calcium
2+
Magnesium 2+
(source)
Thus the chelating substance start off bound to calcium, so
it cannot pick up any new calcium. This, incidentally, is
the proving evidence that chelation does NOT remove
calcium blockage from the arteries -- as many IV
chelation doctors still claim!.
But it is the nature of a chelating substance to "let
go" of the lighter mineral in order to grab the heavier
metal, or more accurately, the metals in the sequence
shown in the above list provided by Dr. Cranton.
Thus the chelating substance starts off bound to calcium, but
it would let go of the calcium if it "bumps into" iron, or even Aluminum.
It would then let go of the aluminum if it bumps into lead. Then, bound to
lead if it bumps into iron, it would NOT let go of the lead to bind to the
iron.
When you are dealing with the artificial amino acid, EDTA,
about half of it stays in the blood stream for an hour or so -- so it is binding
to, and letting go of, heavy metals during that hour, then it is ejected from
the body through the kidneys and urine. The body
considers it a "foreign substance" from the very start
and wants to get rid of it. That is why it stays active
in the body for such a short time.
Cysteine and N Acetyl Cysteine, however, are natural amino
acids. They can stay active in the blood stream for many hours (until they
are used for chelating, used for protein structure building, or converted to
sugar). When EDTA is taken orally it works to bind to metals in the
stomach and intestine. It can also attract metals from inside the body,
through the intestinal wall, to be bound to the EDTA in
the intestine. This EDTA would remain active as long as
it is in the stomach and intestine. Since the
contents of the stomach would usually stay inside the
body for about 24 hours or so, EDTA is active longer when
taken orally than when taken intravenously.
Thus, oral chelation "works" in the body for more hours than
does IV chelation using EDTA only.
Those particles of Cysteine and NAC
that bind to metals? They would
then be considered a "foreign
particle" by the body and processed through the kidney
for elimination in the urine. The same would be
true of the small amount of EDTA that is absorbed into
the body when taken orally.
Intravenous chelation generally relies
only on the artificial Amino Acid, EDTA, and generally
about 2,000 mg of the EDTA is put into a water solution
and dripped into one of your veins over a two or three
hour period. Sometimes 3,000 mg of EDTA is used.
Generally 100% of this EDTA would be in the blood stream,
since it is put directly there.
Oral chelation depends on nutrients being useful when taken
through the mouth. Generally the "chelating substances" are EDTA, Cysteine
and N Acetyl Cysteine. Cysteine and NAC are easily absorbed through the
mouth into the body and blood stream, Since EDTA is an "artificial amino
acid" it is not readily absorbed into the body when taken through the
mouth. The Cysteine and NAC would do their chelating in the normal fashion
of any chelating substance, when taken through the mouth. Since only about
5% of EDTA taken orally gets into the blood, the 95% moves through the stomach
and intestines -- where the "chelating action" is different than when the
chelating substances is in the blood stream.
The one or two hours are called the "half life"
of the EDTA. In about 2 hours, half of the EDTA has been processed out of
the blood stream, through the kidneys, and into the bladder, in the urine,
awaiting elimination. The other half of the EDTA would be working longer,
but you can see that if half of the EDTA is "used up" every two hours, there
would be very, very little left after say 8 hours.
Now, if you just put EDTA in water, there would normally
not be any metals in the water and it might hang on to calcium or it might let
go of calcium -- depending on what WAS in the water.
But, in your body we don't want the EDTA to grab calcium,
so the calcium and EDTA are deliberately included in the same dose -- and in
most cases the EDTA will let go of the calcium it came in with, and grab
something heavier.
So you now have this interesting action --
oral EDTA is removing
metals from the food you have just eaten, but it is also removing metals from
inside the body -- attracting them from inside the body to move through the wall
of the intestine, into the feces in the intestine, to bind with the EDTA that is
still there.
The other ingredients in the formula, mostly cysteine and
NAC, bind to metals from inside the body -- and do it in the same sequential
fashion.
The only minerals that could be removed during chelation
would be those that are heavier than calcium = most of them are harmful.
Zinc is heavier, and not harmful, but my formula provides lots of zinc,
anyway.
The EDTA which is moving through the stomach? Well,
it is NOT going to be eliminated through the kidneys, but through the
feces. Thus, THIS EDTA will actually have a longer time of
effectiveness. The EDTA will remain effective in the intestine as long as
it is still in the intestine -- that would usually be about 24 hours.
During that time it is constantly grabbing metals, letting go of the lighter
ones and switching to the heavier metals.
In this sense EDTA taken orally is much more effective than
EDTA taken intravenously.
When you chelate with Cysteine, or NAC, or intravenous
EDTA, you would look in the urine to test for how much metal is being dumped
from the body. A urine test before using the chelating materials, and another
urine test (for metals) within a couple days after starting the chelating --
would tell you how much of an increase in metal there is. It would not be
unusual for the increase in metal in the urine to be as much as FIFTY
TIMES!
Now, the EDTA going through the stomach and intestine?
It is not being eliminated in the urine, but in the feces, so if you really
wanted to do the proper test you would check a "stool sample" before and after
starting the oral EDTA.
You can see, now that it is a complex question to try to
compare intravenous with oral chelation.
If a person is taking the recommended dose of Super Life
Glow, he is getting 1,800 mg of daily chelating materials, of which 500 mg is
EDTA.
If a person is taking an IV treatment, he would be getting
between 2,000 and 3,000 mg of EDTA. The EDTA would NOT be active for very
long when taken intravenously, and would be active longer when taken
orally.
There is another issue. Intravenous EDTA would be all
working within the blood stream, and generally its ONLY action would be to
remove metals.
Cystine and NAC, however, would not be active ONLY as
binding materials. These are natural amino acids and the body may well have
other uses for them besides chelating metals. It would not be very
possible to know how much Cysteine, for instance, would be used to remove metals
and how much would be used for other purposes in the body.
Is this a complex question? or not?
Finally, perhaps the best way of comparing is to simply
look at results of use, rather than the mechanics of action.
EDTA taken intravenously seems faster than oral
chelation. People will often get dramatic changes in their body after only
three or four IV treatments. These dramatic changes usually take 30 days
with oral chelation.
My personal belief on this is that if you have an urgent
need for fast action, IV chelation would be the best way to go.
But, after about 30 days, or perhaps 60, I think the daily
oral chelation would be at least as effective, and probably more effective, than
a series of 30 treatments of IV EDTA.
I have a complete analysis of one of the most recent
approaches to chelation -- using EDTA in a suppository. It would be more
effective through the mouth, since it would stay active longer, but the
suppositories are being hyped as prescription only, provided only by doctors,
and costing as much as $50 for one suppository containing 750 mg of EDTA.
Click
here for that story.
There are also many examples of different combinations of the
three different oral chelation formulas -- click
here.
One more thing.
Mercury is a common toxic metal in the body. It is
generally accepted that EDTA, taken intravenously, does NOT remove
mercury. However, Cysteine and N Acetyl Cysteine do remove
mercury. So, intravenous EDTA is not useful in removing one of the most
dangerous of all toxic metals we have in our bodies, while oral chelation does
remove mercury.
There are some interesting studies, not well known or
validated, that show that oral EDTA may, in fact remove mercury, into the
feces. This would make the oral chelation approach even more valuable than
the intravenous approach.
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