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Med Help International the Patient Medical Information Center

Questions in The Heart Forum are being answered by doctors from The Cleveland Clinic Heart Center, consistently ranked the #1 Heart Center in America.


Subject: coumadin and alcohol
Topic Area: Heart Disease
Forum: The Heart Forum

Question Posted By: Cathy on Friday, August 28, 1998
 

My husband has Marfan's syndrome, and had his aortic valve and arch
replaced (both are artificial/mechanical) about five years ago due to
an aortic disection. He is 23 years old now. He was put on coumadin,
3 mg per day, and also atenelol 100 mg per day. He recovered well and
hasn't had any problems since.

My question has to do with alcohol consumption. Is it bad for someone
with Marfan's to drink? Or for someone taking his medications? He has
a drink now and then, not a lot, but when I've asked him about it he says
it's fine as long he doesn't get hurt (since the blood would clot more
slowly on coumadin, and even more slowly with alcohol in the system). Am I
being paranoid here? I want him to enjoy himself, and truthfully nothing
bad has ever resulted from him having a drink now and then. He says his
doctor OK'd it as long it was moderate, but I still worry. Also, if
alcohol increases the effect of coumadin, how much does it increase it by,
and for how long? Is it really OK as long he's just careful not to injure
himself? And how much alcohol is "moderate"? This has been bothering me
for a while now, so any input would be appreciated.

_______________________________________________________________

Dear Cathy, thank you for your question. Alcohol can interact with coumadin through it's metabolism in the liver. Alcohol is degraded by enzymes in the liver. Clotting factors are also made in the liver so coumadin exerts its effect in the liver. Certain clotting factors depend on vitamin K to be produced. Coumadin inhibits vitamin K to cause the blood the be "thinned." When execesive alcohol is consumed, the liver is "preoccupied" with degrading the alcohol and may actually be damaged by the alcohol. When this occurs, the effect of vitamin K is magnified so the blood can be over anticoagulated. It's difficult to say how long this effect lasts since the metabolism of alcohol and coumadin is highly variable in different patients. Also, since alcohol can impair the senses and put patients at a higher risk of falling or having an accident, the risk of bleeding while on coumadin and alcoholo can be increased. Typically, I advise patients taking coumadin to have no more than one drink per day (12 oz. beer, 4 oz. wine, 1 ox. hard liquor) which would be considered "moderate" and should not cause any problems. Certainly, more than 2-3 drinks/day would be considered excessive when someone is taking coumadin. I think your husband should do fine with moderate alcohol consumption but only his physician can determine what is "moderate" consumption in his case. Alcohol consumption does not affect the disease process of Marfan's syndrome I hope you find this information useful.

Information provided in the heart forum is for general purposes only. Specific diagnoses and therapies can only be provided by your physician.


BLOOD THINNING OR ANTICOAGULANTS - COUMADIN

There are a number of blood thinning agents that are available in medicine. The drugs used over the years have included Coumadin, Heparin, Low molecular weight heparin or Lovenox, aspirin, Plavix, Ticlid, Persantine and Anturane.

What It Does 

Coumadin (warfarin) is a drug that is taken by mouth. It acts on various components of the blood clotting mechanism to prevent blood clotting in the body. A cascade of known blood factors act in sequence to cause the blood to form a blood clot. This activity is partly disrupted by the use of Coumadin.

What Test Is Required and Frequency to Control the Use of Coumadin

A blood test called the Prothrombin time is used to control the amount of Coumadin that an individual takes. It is standardized by an international unit called the INR, which has worldwide application. It is suggested by most cardiologists that a blood test for the Coumadin dosage be obtained at least every three weeks. Coumadin should be used at the end of the day so that one's blood test can be evaluated early in the day and the amount of Coumadin medicine prescribed changed if necessary by reviewing the blood test ie. the INR.

Health Conditions Requiring Coumadin

 There are a number of cardiac and other health conditions which prompt and advise the use of the anticoagulant, Coumadin. Those patients with most prosthetic (artificial) valves of the heart require Coumadin. The rhythm abnormality called atrial fibrillation, or an irregular heartbeat requires Coumadin. Big hearts or dilated hearts (cardiomyopathy) frequently require Coumadin. Pulmonary embolism or blood clots in the lung and thrombophlebitis or blood clots in the legs require anticoagulation with Coumadin. The distinct entity of pulmonary hypertension or high blood pressure in the lung artery frequently requires anticoagulation with Coumadin. Other specific blood clotting disease (coagulopathies) also may require the use of anticoagulation with Coumadin.

Over Medication With Coumadin

Over medication with Coumadin can cause severe bleeding and death. Bleeding may occur inside the head, inside the heart, inside the kidneys, the bowel or the lung. It commonly is seen as severe bruising in the skin. Adjustment of the Coumadin dosage would be essential.

Inadequate Anticoagulation of Blood Thinning

 These result is serious consequences as well with patients having cerebral vascular accidents (strokes), heart attacks or blood clots going to any organ or to any extremity.

When to Take Your Coumadin

 It is recommended that you take your Coumadin at the same time each day, usually before or after the evening meal. On the day of your Protime this allow your physician to reach you before you have taken your medication in case any adjustments are necessary.

SAFETY TIPS

Guard against cuts; wear shoes. When gardening or doing similar work wear gloves. The use of an electric shaver is advised.

Avoid food fads, crash diets or marked changes in eating habits. Certain foods are high in Vitamin K. These need not be avoided; however, a marked change in the amount of these will alter your response to Coumadin. These are alfalfa, cabbage, cauliflower, liver, spinach, soybeans, fish and fish oils.

Alcohol enhances the effect of Coumadin. If you drink, ask your physician about guidelines for amounts that are safe.

Don't play contact sports that can subject you to injury.

Have regular dental checks to assure oral hygiene and avoid disease. Remember to inform your dentist that you take Coumadin.

Women should notify their doctors as soon as they suspect they are pregnant.

Many factors can influence Coumadin response and Protime levels. These include diarrhea, decreased liver or kidney function, emotional upsets, harsh laxatives, vitamins, infections, weather changes, antibiotics, aspirin and other drugs.

You should wear or carry identification indicating that you are taking Coumadin. Cards are available and most pharmacies carry bracelets or necklaces with this information.

CALL YOUR DOCTOR IF:

FACTORS THAT INCREASE YOUR PROTIME ( MAKE YOUR BLOOD TOO THIN)

Internal Factors
  • carcinoma 
  • liver disorders 
  • collagen disease 
  • infectious hepatitis 
  • congestive heart failure 
  • jaundice 
  • diarrhea 
  • poor nutritional state 
  • elevated temperature 
  • Vitamin K deficiency

 

External Factors
  • alcohol 
  • Coumadin overdosage 
  • anesthetics 
  • prolonged hot weather 
  • prolonged narcotics 
  • unreliable protime blood tests

 

MEDICATIONS

Allopurinol ( Zyloprim) steroids
antibiotics Chloral Hydrate
Diabenese (chlorpropamide) Tagamet (cimetidine)
Atromid-S (clofibrate) Dextran )
Hyperstat (diazoxide Antabuse (disulfiram)
Edecrin (ethacrynic acid) Nalfon (fenoprofen)
Glucogon Ibuprofen (Motrin, Advil, Nuprin)
Indocin (idomethacin) Aldomet (methyldopa)
Ritalin (methylphenidtae) Flagyl (metronidazole)
Nardil (MAO inhibitors) Anaprox (naproxen)
Pamelor (nortriptyline) Butazolidine (phenylbutazone)
Dilantin (phenytoin) Quineglute (quinidine)
Quinine salicylates (aspirin, Bufferin)
Anacin Darvon Compound
Anturane (sulfinpyrazone) Bactrim (sulfa drugs)
Clinoril (sulindac) Synthroid (thyroid drugs)
levothyroxin Orinase (tolbutamid)

 

FACTORS THAT DECREASE PROTIME ( MAKE YOUR BLOOD TOO THICK)

Internal Factors
  • diabetes mellitus
  • hyperlipidemia
  • edema
  • hypothyroidism
  • hereditary resistance to coumadin therapy
External Factors
  • alcohol 
  • Coumadin underdosage
  • unreliable protimes
  • diet high in Vitamin K (begetable, fish, fish oil)

MEDICATIONS

adrenocortical steroids
Actifed
Benadryl (diphenhydramine)
Nyquil
Triaminic
Seconal
Chloral hydrate
Questran (cholestryramine)
Placidyl (ethchlorvynol)
Haldol (haloperidol)
oral contraceptives
Dilantin( phenytoid)
Vitamin C
antacids (Riopan, Mylanta, etc)
Atarax
Dimetapp
Phenergan
Anytal
Nembutal
Librium (chlordiazepocxide)
estrogens
Doriden (glutethimide)
Miltown (meprobamate)
paraldehyde
Rifadin (rifampin)
Vitamin K

MEDICATIONS CONTAINING SALICYLATES

Alka Seltzer
APC
Ascriptin
Aspirin, Children's
Bufferin
Cope
Coricidin-D
Darvon Compound
Ecotrin
Equagesic
Excedrin PM
4 Way Cold Tablets
Midol
Norgesic
Pabirin
Palgesic
Percodan
Phenergan compound
St. Joseph aspirin
Synalog
Soltice cold tablets
Triaminicin
Anacin
Aspirin
Aspergum
Bayer
Congesprin
Coricidin
Darvon
Dristan
Empirin
Excedrin
Fiorinal
Liquiprin
Nuprin
Novahistine
PAC compound
PC-65
Phenaphen
Pyrroxate
Supac
Sine-Aid
Quiet World
Vanquish

These medications contain aspirin (salicylates) and should not be used if you are using Coumadin. This is only a partial list, many medications contain aspirin and you should check the labels of all medications very carefully. Tylenol, Datril or other brands of Acetaminophen should be usedfor minor aches or pains. 

The importance of blood thinning or anticoagulation with Coumadin is very important for patient health. Adjustments of the Coumadin dosage should be made at least every three weeks by testing the blood Prothrombin time and the INR. Medications are prescribed by other physicians should be discussed with the physician or cardiologist who is caring for the Coumadin dosage. Failure to do so may result in catastrophic experiences.

The statements provided in this report are for information only.  This is not intended to be medical advice.  Each individual may react differently depending on a variety of circumstances.  It is therefore imperative you consult your physician prior to following any of the contents of this report.  CardioDoc.net and CardioDoc.org disclaim any and all liability.

 



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