Favorable Studies On Ozone Therapy
Also, read here:
The Whole Story About Subnormal Body
Temperature And Ozone
Source
Extracorporeal blood oxygenation and ozonation (EBOO)
in man. preliminary report.
Di Paolo N, Bocci V, Garosi G, Borrelli E, Bravi A, Bruci A, Aldinucci C,
Capotondo L.
Nephrology and Dialysis Department, Azienda Ospedaliera Senese, Siena, Italy.
Autohemotherapy with ozone has been used for four decades with encouraging
results but, owing to the lack of clinical studies, it has never been adopted by
orthodox medicine.
Confident of the valid principles of ozone therapy, we
have endeavoured to increase its therapeutic efficacy.
Over a ten-year period we have developed an apparatus that
makes it possible to treat large quantities of blood with ozone in
extracorporeal circulation (extracorporeal blood oxygenation and ozonation EBOO).
One of us volunteered to test the system and after six
treatments noted the disappearance of two lipomas.
This prompted us to treat a patient with Madelung disease
and several patients with atherosclerotic vasculopathy.
Besides showing therapeutic effects, the preliminary
results indicate that EBOO is clinically valid, without side-effects and worthy
of testing in various diseases.
PMID: 10741810 [PubMed - indexed for MEDLINE]
Source
Evaluation of ozonated oxygen in an experimental animal model
of osteomyelitis as a further treatment option for skull-base osteomyelitis.
Steinhart H, Schulz S, Mutters R.
Universitats HNO-Klinik Homburg/Saar, Germany.
The standard treatment of chromic skull-base osteomyelitis is antibiotics and
surgical removal of sequestrums.
Hyperbaric oxygen therapy has been found to be a useful
method for managing refractory cases of chronic osteomyelitis.
Since a minimal blood supply is needed for hyperbaric
oxygen therapy, chronic osteomyelitis can produce necrotic infected areas that
are not nutrified and therefore not assessable for hyperbaric oxygen therapy.
Ozone is known to be an oxidizing medium with a strong
bactericidal effect.
We investigated the influence of locally applied ozonated
oxygen on the development of chronic osteomyelitis in an experimental animal
model using the femur of the rabbit.
The proximal sides of the femurs of 40 rabbits were
prepared and a needle inserted into the intramedullary cavity. Osteomyelitis was
induced with an infusion of Staphylococcus aureus and sodium morrhuate into the
bone. The needle was left in a intramedular location. After a 4-week delay
animals were randomly separated into treatment and control groups.
The infected femur of treated animals was flushed three
times a day with 20 ml of ozonated oxygen at an ozone concentration of 107
micrograms/ml O2 over periods of 2 or 4 weeks.
Clinical, radiographic and microbiological findings
were documented.
Chronic osteomyelitis occurred in all animals. Ten rabbits
were excluded from further study during the investigation because of excessive
weight loss (> 15% of the original weight).
Bacterial cultures showed no significant reduction of S.
aureus concentrations in the ozone-treated group, although comparison of
radiographic results revealed less serious osteomyelitis-related bone damage in
these animals (P < 0.01).
These findings indicate that refractory osteomyelitis in
the head and neck may benefit from locally applied "flush" therapy with ozonated
oxygen in addition to treatment with antibiotics, surgery and hyperbaric oxygen.
PMID: 10234486 [PubMed - indexed for MEDLINE]
Source
Evaluation of a new heparin bonding process in prolonged
extracorporeal membrane oxygenation.
Nojiri C, Hagiwara K, Yokoyama K, Kurbayashi E, Hidaka K,
Ishida N, Horiuchi K, Oshiyama H, Nogawa A, Kido T, et al.
Institute of Biomedical Science, Terumo Corporation, R&D Center, Kanagawa,
Japan.
A novel heparin bonding method has been developed for in situ surface
modification using ozone oxidation, and evaluated in vitro and in vivo during
prolonged extracorporeal membrane oxygenation (ECMO) experiments.
The ECMO system consisted of a Capiox hollow fiber
membrane oxygenator (MO; Terumo Corp., Tokyo, Japan) with an integral heat
exchanger, a Capiox centrifugal pump (CP), and an extracorporeal circuit.
The blood contacting surfaces of the system were
completely modified using the heparin bonding process, and evaluated in a
chronic sheep model for extended period of time, ranging from 96 to 168 hr,
under minimal systemic heparinization.
The heparin bonded surface was able to maintain high
levels of heparin bioactivity, and showed improved blood compatibility in in
vitro epifluorescent video microscopy experiments by suppressing platelet
adhesion/activation and complement activation. For the ECMO experiments,
extracorporeal blood flow was maintained at 3 L/min and the activated clotting
time was maintained at 150 sec.
There was no significant change in the gas transfer
capability or mean pressure drop across the MO over experimental times of up to
168 hr.
Platelet count and other coagulation parameters remained
stable within the physiologic range throughout the experiment. There were no
detectable thrombi in the CP, tubing, or connectors in the test circuit. Local
thrombus formation was noted in a stagnant area of the MO, although this did not
interfere with its function or lead to any significant embolization.
Based on these results, the heparin bonded ECMO system
appears to be a safe and effective device for prolonged extracorporeal
circulation under minimal systemic heparinization.
PMID: 8573868 [PubMed - indexed for MEDLINE]
Source
Hyperbaric oxygen, oxygen-ozone therapy, and rheologic
parameters of blood in patients with peripheral occlusive arterial disease.
Verrazzo G, Coppola L, Luongo C, Sammartino A, Giunta R, Grassia A, Ragone R,
Tirelli A.
Department of Gerontology, Geriatry and Metabolic Diseases, Second University of
Naples, Italy.
For many years, clinical practice has consolidated the use of both hyperbaric
oxygen and oxygen-ozone therapy in the treatment of peripheral occlusive
arterial disease (POAD).
We investigated the influence of these treatments on
hemorrheologic parameters that play an important role in the pathogenesis and
the clinical course of arteriosclerosis.
Two groups of 15 patients suffering from POAD, assigned at
random either to a cycle of HBO therapy or O2-O3 therapy, were evaluated for
blood viscosity, erythrocyte filterability, hematocrit value, fibrinogen
concentration, and thrombin time.
The O2-O3 therapy caused a significant
increase of erythrocyte filterability and a significant decrease of blood
viscosity.
By contrast, HBO therapy did not produce any significant
change.
The increase of lipid peri-oxidation, proved by raised
malonyldialdehyde plasma levels, seems a likely mechanism involved in the
hemorrheologic effects of O2-O3 therapy.
Publication Types:
- Clinical Trial
- Randomized Controlled Trial
PMID: 7742706 [PubMed - indexed for MEDLINE]
Source
[Oxygen concentrators are not ozone concentrators]
[Article in German]
Mitlehner W.
I. Innere Abt., Urban Krankenhaus Berlin.
Ozone is a constituent of the natural ambient atmosphere and occurs dependent on
weather and environment in concentrations that can trigger airway inflammation.
Oxygen concentrators are employed in oxygen long-term
therapy and produce in the room air a mixture of concentrated oxygen and
residual gases of unknown ozone concentration.
Hence, we studied the ozone concentration of the air
supplied by the oxygen concentrator, both under normal conditions in the room
air and with increased ozone concentration of the air in the room.
Both under room air conditions and under increased ozone
concentrations of up to 12 ppm in the surrounding air the residual gas mixture
of the air produced by the oxygen concentrator did not contain any ozone
concentration beyond 0.005 ppm.
This prompts us to suggest that the oxygen concentrators
examined by use are ozone eliminators rather than ozone concentrators.
PMID: 8378295 [PubMed - indexed for MEDLINE]
Source
Comment in:
Protection by N-acetylcysteine against pulmonary
endothelial cell damage induced by oxidant injury.
Sala R, Moriggi E, Corvasce G, Morelli D.
Zambon Research S.p.A., Bresso, Milan, Italy.
The protective effect of N-acetylcysteine (NAC) against oxidant lung injury was
investigated in a model of acute immunological alveolitis in the rat.
Intrapulmonary immune complex deposition into rat lungs,
induced by intratracheal infusion of immunoglobulin G (IgG) anti-bovine serum
albumin (BSA) antibodies and intravenous injection of the antigen, caused lung
damage associated with a marked decrease in [14C]5-hydroxytryptamine ([14C]5HT)
uptake capacity, taken as a biochemical marker of endothelial cell function.
The oral administration of a single dose of NAC (2
mmol.kg-1) 60 min before antigen/antibody (Ag/Ab) treatment was effective in
preventing pulmonary endothelial cell [14C]5HT uptake loss induced by immune
complex deposition.
The mechanisms involved in this lung protective action of
NAC were investigated by studying the antioxidant activity of NAC on
hypoxanthine/xanthine oxidase-induced lung damage in vitro, and the
effectiveness of the drug as lung glutathione (reduced form) (GSH) precursor in
diethylmaleate-depleted rats.
The results obtained provide further
evidence on the ability of NAC to reduce the susceptibility of lung tissue to
free radical-induced damage, by potentiating the antioxidant defence systems.
PMID: 8472835 [PubMed - indexed for MEDLINE]
Source
Inactivation of viruses and bacteria by ozone, with and
without sonication.
Burleson GR, Murray TM, Pollard M.
Selected organisms with public health significance were placed
in a reaction chamber for treatment by ozonation, by ozonation and sonication,
by sonication, or by sonication during oxygenation.
Vesicular stomatitis virus, encephalomyocarditis virus,
GDVII virus, Staphylococcus aureus, Pseudomonas fluorescens, Salmonella
typhimurium, enteropathogenic Escherichia coli, Vibrio cholerae, and Shigella
flexneri were inactivated by treatment with ozone.
When microorganisms were suspended in phosphate-buffered
saline, they were inactivated rapidly by treatment with ozone.
However, microorganisms suspended in secondary effluent
from a wastewater treatment plant required longer contact times with ozone for
complete inactivation. Simultaneous treatments by ozonation and sonication
reduced the contact time for complete inactivation of microorganisms in
secondary effluent.
Treatment by sonication alone or sonication and
oxygenation did not inactivate microorganisms.
Therefore, the simultaneous
treatment of microorganisms in secondary effluent with ozone and sonication
resulted in a synergistic effect.
PMID: 163616 [PubMed - indexed for MEDLINE]
Source
[Phospholipids under combined ozone-oxygen administration]
[Article in German]
Muller-Tyl E, Hernuss P, Salzer H, Reisinger L, Washuttl J, Wurst F.
The parenterally application of oxygen-ozone gas mixture gives
good resultats in the treatment of various deseases.
Ozone seems to influence the metabolic process of fat, so
it was of interest to analyse this influence especially to phospholipids.
40 women with gynaecological cancer got 10 ml oxygen-ozone
gas mixture with a content of 450 gamma ozone into the cubital vene. Venous
blood was removed before and 10 minutes after application and the level of
lecithin, lysolecithin, cephalin and spingomyelin was determined by the method
of Randerath.
A decrease of all four substances was obvious, although
all values remained in normal range.
PMID: 1243775 [PubMed - indexed for MEDLINE]
Source
[Water disinfection: comparative activities of ozone and
chlorine on a wide spectrum of bacteria]
[Article in Spanish]
Korol S, Fortunato MS, Paz M, Sanahuja MC, Lazaro E, Santini P, D'Aquino M.
Departamento de Sanidad, Nutricion, Bromatologia, Universidad
de Buenos Aires, Argentina.
Ozone and chlorine are agents that disinfect by destroying, neutralizing or
inhibiting the growth of pathogenic microorganisms.
The treatment of drinking water with ozone has shown to be
more efficient against spores of Bacillus subtilis. It was observed that the
ozone already in dose of 0.35 mg/l produced the reduction of at least 5 log in
populations of approximately 1 x 10(6) cells/ml of Escherichia coli, Vibrio
cholerae, Salmonella typhi, Yersinia enterocolitica, Pseudomonas aeruginosa,
Aeromonas hydrophila, Listeria monocytogenes and Staphylococcus aureus.
With a dose of 0.50 mg/l of chlorine, the reduction was
much smaller for the tested microorganisms (except Vibrio cholerae), while the
effect of 2 mg/l of chlorine was similar to the ozone treatment. For spores of
Bacillus subtilis, the reduction observed with ozone concentrations of 0.35 and
0.70 mg/l was of almost 3 log, while no considerable effect was obtained with
chlorine in the tested conditions.
Our results have shown that both disinfectans were
consumed during the treatment period, probably because of the own water demand
and the added bacterial mass.
PMID: 8850129 [PubMed - indexed for MEDLINE]
Source
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