Karl note: Naproxen is a prescription drug, but Naproxen Sodium is an over-the-counter drug. The Naproxen Sodium is the same as the prescription drug, but is less strong. It has sodium added to the drug. A medical doctor I trust has suggested that Naproxen is not as harmful as most other related drugs. Specifically I understand that Naproxen impairs mental ability far less than, for instance, aspirin.
I also now use "FYI" (For Your Inflammation) to reduce inflammation, but do not find that it relieves pain.
Naproxen/Naproxen Sodium
Also indexed as: Aleve®, Anaprox®, Napralen®, Napron X®, Naprosyn®
Interactions with Dietary Supplements
Copper
Supplementation with copper may enhance the anti-inflammatory effects of
NSAIDs while reducing their
ulcerogenic effects. One study found that when various anti-inflammatory
drugs were chelated with copper, the anti-inflammatory activity was increased.1
Animal models of inflammation have found that the copper chelate of
aspirin
was active at one-eighth the effective dose of aspirin. These copper complexes
are less toxic than the parent compounds, as well.
Lithium
Lithium is a mineral that may be present in some supplements and is also used
in large amounts to treat mood disorders such as manic-depression (bipolar
disorder). Most NSAIDs inhibit the excretion of lithium from the body,
resulting in higher blood levels of the mineral, though
sulindac
may have an opposite effect.2 Since major changes in lithium blood
levels can produce unwanted side effects or interfere with its efficacy,
NSAIDs should be used with caution, and only under medical supervision, in
people taking lithium supplements.
Iron
NSAIDs cause gastrointestinal (GI) irritation, bleeding, and iron loss.3
Iron supplements can cause GI irritation.4 However, iron
supplementation is sometimes needed in people taking NSAIDs if those drugs
have caused enough blood loss to lead to
iron deficiency. If both iron and naproxen are prescribed, they should be
taken with food to reduce GI irritation and bleeding risk.
Potassium
Naproxen has caused kidney problems and increased blood potassium levels,
especially in older people.5 6 People taking naproxen
should not supplement potassium without consulting with their doctor.
Sodium
Naproxen may cause sodium and
water
retention.7 It is healthful to reduce
dietary
salt intake by decreasing the use of table salt and avoiding heavily
salted foods.
Licorice (Glycyrrhiza glabra)
The flavonoids found in the extract of licorice known as DGL (deglycyrrhizinated
licorice) are helpful for avoiding the irritating actions
NSAIDs
have on the stomach and intestines. One study found that 350 mg of chewable
DGL taken together with each dose of
aspirin
reduced gastrointestinal bleeding caused by the aspirin.8 DGL has
been shown in controlled human research to be as effective as drug therapy (cimetidine)
in healing stomach ulcers.9
White willow bark (Salix alba)
White willow bark contains salicin, which is related to
aspirin.
Both salicin and aspirin produce anti-inflammatory effects after they have
been converted to salicylic acid in the body. The administration of
salicylates like aspirin to individuals taking oral NSAIDs may result in
reduced blood levels of NSAIDs.10 Though no studies have
investigated interactions between white willow bark and NSAIDs, people taking
NSAIDs should avoid the herb until more information is available.
Interactions with Foods and Other Compounds
Food
Naproxen should be taken with food to prevent gastrointestinal upset.11
Alcohol
Naproxen may cause drowsiness, dizziness, or blurred vision.12
Alcohol may intensify these effects and increase the risk of accidental
injury. Use of alcohol during naproxen therapy increases the risk of stomach
irritation and bleeding. People taking naproxen should avoid alcohol.
Summary of Interactions for Naproxen
| Depletion or interference | Iron |
|---|---|
| Adverse interaction |
Lithium* Sodium* White willow* |
| Side effect reduction/prevention |
Copper* Licorice |
| Supportive interaction | Copper* |
| Reduced drug absorption/bioavailability | None known |
| Other (see text) | Potassium |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135–48.
2. Olin BR, ed. Central Nervous System Drugs, Analgesics and Anti-inflammatory Drugs, Nonsteroidal Anti-inflammatory Agents, In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 1172–90.
3. Bjarnason I, Macpherson AJ. Intestinal toxicity of non-steroidal anti-inflammatory drugs. Pharmacol Ther 1994;62:145–57.
4. Threlkeld DS, ed. Blood Modifiers, Iron-Containing Products. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jun 1998, 62–9a.
5. Bailie GR. Acute renal failure. In Applied Therapeutics: The Clinical Use of Drugs, 6th ed. Vancouver, WA: Applied Therapeutics, 1995, 29–33.
6. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307–14 [review].
7. Threlkeld DS, ed. Central Nervous System Drugs, Nonsteroidal Anti-Inflammatory Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1993, 251n–1o.
8. Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 1979;14:605–7.
9. Morgan AG, McAdam WAF, Pascoo C, Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut 1982;23:545–51.
10. Olin BR, ed. Central Nervous System Drugs, Analgesics and Anti-inflammatory Drugs, Nonsteroidal Anti-inflammatory Agents, In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 1172–90.
11. Threlkeld DS, ed. Central Nervous System Drugs, Nonsteroidal Anti-Inflammatory Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1992, 251n–1o.
12. Threlkeld DS, ed. Central Nervous System Drugs, Nonsteroidal Anti-Inflammatory Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1992, 251n–1o.
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